Stress hyperglycaemia

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Glucagon orchestrates stress‐induced hyperglycaemia

Hyperglycaemia is commonly observed on admission and during hospitalization for medical illness, traumatic injury, burn and surgical intervention. This transient hyperglycaemia is referred to as stress-induced hyperglycaemia (SIH) and frequently occurs in individuals without a history of diabetes. SIH has many of the same underlying hormonal disturbances as diabetes mellitus, specifically absol...

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Hyperglycaemia as part of the stress response: the underlying mechanisms.

Stress hyperglycaemia is a distinctive clinical feature of critical illness. Stress mediators, namely stress hormones, cytokines and the central nervous system, interfere with normal carbohydrate metabolism, especially in the liver and skeletal muscle. Central insulin resistance, defined as increased hepatic gluconeogenesis and glucose output despite abundant endogenous insulin levels, appears ...

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Stress hyperglycaemia in patients with first myocardial infarction.

OBJECTIVE To investigate the incidence of stress hyperglycaemia at first acute myocardial infarction (MI) with ST-segment elevation, occurrence of stress hyperglycaemia as a manifestation of previously undiagnosed abnormal glucose tolerance (AGT), and its relation to stress hormone levels. MATERIALS AND METHODS   The population of this prospective cohort study consisted of 243 patients. On ad...

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Hyperglycaemia and pulmonary infection.

Pathophysiological stress from acute illness causes metabolic disturbance, including altered hepatic glucose metabolism, increased peripheral insulin resistance and hyperglycaemia. Acute hyperglycaemia is associated with increased morbidity and mortality in patients in intensive care units and patients with acute respiratory disease. The present review will consider mechanisms underlying this a...

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Hyperglycaemia and cancer risk

A recent Swedish prospective study on hyperglycaemia and cancer risk (1) showed an association with total cancer risk in women, and in women and men combined, for several cancer sites. The cancer incidence was compared with both fasting glucose and glucose 2 h after a 75 g glucose load. For women the relative total cancer risks for the top versus bottom quartiles were in the range of 1.3, i.e. ...

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ژورنال

عنوان ژورنال: The Lancet

سال: 2009

ISSN: 0140-6736

DOI: 10.1016/s0140-6736(09)60553-5